Vitiligo: interplay between oxidative stress and immune system
نویسندگان
چکیده
منابع مشابه
Vitiligo: interplay between oxidative stress and immune system.
Vitiligo is a multifactorial polygenic disorder with a complex pathogenesis, linked with both genetic and non-genetic factors. The precise modus operandi for vitiligo pathogenesis has remained elusive. Theories regarding loss of melanocytes are based on autoimmune, cytotoxic, oxidant-antioxidant and neural mechanisms. Reactive oxygen species (ROS) in excess have been documented in active vitili...
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Vitiligo is an acquired dermatological disease frequently associated with autoimmune thyroid disorders. Several theories have been proposed so far to unravel the complex vitiligo pathogenesis. Currently, the autocytotoxic and the autoimmune theories are the most accredited hypothesis, since they are sustained by several important clinical and experimental evidences. A growing body of evidences ...
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Superantigens interact with the immune system by binding to major histocompatibility complex (MHC) class II proteins and activating T cells through the variable region of the T cell receptor beta-chain. Through this means they can cause massive proliferation and then death of a large proportion of T cells. Superantigens are produced by bacteria, mycoplasmas, retroviruses, and probably by other ...
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It is well recognized that energy metabolism is linked to the production of reactive species and critical enzymatic processes allied to metabolic pathways can be affected by redox reactions. Both protein and lipid oxidation are involved in the aging process as well as the onset and progression of many age-related diseases. As such, the capacity to identify specific targets and detect subsequent...
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Neurodegenerative processes may be involved in the pathogenesis of schizophrenia. Brain-derived neurotrophic factor (BDNF), the most widely distributed neurotrophin and oxidative stress (OS) may be critical for several pathological manifestations of neurodegenerative disorders. Accumulating evidence suggests that both BDNF and OS may be involved in the pathophysiology of schizophrenia. However,...
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ژورنال
عنوان ژورنال: Experimental Dermatology
سال: 2013
ISSN: 0906-6705
DOI: 10.1111/exd.12103